Mutations

Cancer is a disease of genes that gone out of control. Certain genes that direct the orderly replication of cells have malfunctioned and cause the cell to divide unabated. Eventually, these damaged cells spread into neighboring cells of other tissues and multiply all over the body. All cancer is genetic in origin, that is, it is initially set off by altered genes. However, just a tiny portion of cancer is inherited: a mutation carried in reproductive cells, passed on from one generation to the next, and present in cells throughout the body. Most cancers come from random mutations that develop in body cells during one's lifetime – either as a mistake when cells are going through cell division or in response to injuries from environmental agents such as radiation or chemicals. Cancer usually arises in a single cell. The cell's progress from normal to malignant to metastatic appears to follow a series of distinct steps, each one controlled by a different gene or set of genes. Several types of genes have been implicated. Oncogenes normally encourage cell growth; when mutated or overexpressed, they can flood cells with signals to keep on dividing. Tumor-suppressor genes normally restrain cell growth; when missing or inactivated by a mutation, they allow cells to grow and divide uncontrollably. (The inherited genes that predispose for breast and ovarian cancer, Li-Fraumeni syndrome, retinoblastoma, Wilms' tumor, and familial adenomatous polyposis are malfunctioning tumor-suppressor genes.) DNA repair genes appear to trigger cancer – and perhaps other inherited disorders – not by spurring cell growth but by failing to correct mistakes that occur as DNA copies itself, letting mutations accumulate at thousands of sites. (Genes that have been linked to hereditary colon cancer are such â€Å"proofreader† genes.)   

Paradise Lost by John Milton Essay

1 – ‘Language has the ability to make sin look attractive’ Tis Pity was published by John Ford in 1633 and is set in Italy, the heart of the Renassiance. John Milton published Paradise Lost in 1667, relatively soon after John Ford, and was the first epic poem to be written in blank verse. Both writers push the boundaries of literature by exploring untouched, taboo subjects: incest and The Fall of Man. During this period of time, soon after the Renassiance period, many artists and writers were challenging society by introducing a range of different styles and genres. This meant that Ford and Milton both intended to tempt controversy through their pieces of literature; yet, the seductive choice of language has instead caused an attractiveness to both texts. It is this attraction to the language, and utter skill behind these writer’s intentions, that has enabled both texts to withstand the test of time. In Book Nine of Paradise Lost, Milton begins to introduce Satan as the Serpent; however, he manages to draw the audience away from Satan’s intentions by presenting his physical beauty. As the Serpent ‘Addressed his way’ towards Eve, with the desire to cause corruption, he moves ‘not with intended wave’. Instead, he towers ‘fould above fould a surging Maze’, with the colours of ‘Verdant Gold’. By giving the Serpent distinct characteristics, he is separating him from the other creatures in the Garden of Eden, therefore drawing Eve’s attention to his uniqueness. The repetition of ‘fould above fould’ gives the sense of an illusion, something which Eve’s eyesight is unable to comprehend; which is then reinforced by ‘surging Maze’, giving this illusion speed and power, causing a greater confusion on Eve’s behalf. The vivid description of ‘verdant Gold’ gives the Serpent a very rich colouring, thus reiterating his importance in the Garden. When Satan finally decides to confront Eve, he becomes ‘erect’, giving himself a sense of empowerment. This is when Milton’s narration confirms the beauty of his language, as he mentions how ‘pleasing was his shape / and lovely’. For an audience, this outside interpretation almost gives a sense of comfort, as they too are lost in his physical beauty. Finally, as the Serpent begins to speak, his ability to compliment and seduce enables him to make his way ‘into the heart of Eve’. There are clear similarites between Satan in Paradise Lost and Vasques in Tis Pity: both have a masterful use of rhetoric. As Vasque attempts to gather information from Putana, he mentions how her – by proving themselves  to be devoted to these women, they are appealing to their naivity and giving a false sense of trust. Their seductive use of language causes them to become ‘impassioned’, as they begin to realise their ability to attract these women. The absence and withdrawal of language in both texts is equally as attractive to an audience. In Paradise Lost Book Nine, the pivotal point when Eve eats the Forbidden Fruit is simply expressed in four words, ‘she plucked, she eat’. The use of these monosyllables reinforces how emphasis can be achieved through simplicity. Extending on this further, Milton’s constant elaboration and care to detail is deliberately dismissed here to send an even greater message to his audience: mankind cannot blame Eve for causing the Fall as she simply ‘ate’ the fruit. By refusing to focus on Eve’s decision to eat the Fruit, he is daringly challenging conventional views that women are the only cause of sin. John Ford in Tis Pity has a similar intention through his portrayal of Hippolyta; her refusal to be silenced goes against the view of women’s inferiority. This is achieved in Act Two Scene two, as she powerfully enters with ‘Tis I;’. These two words are separate from the rest of her speech in order to hold suspense and give her a greater presence on stage. Ford’s intention is for the audience to immediately be drawn to her in preparation for her criticism towards Soranzo. As both Ford and Milton are so skilled in writing ‘attractively’ and deliberately trying to engage an audience, it is even more effective when they suddenly withdraw; the audience become responsible in using their own imagination, in attempt to understand the message these writers intend to express. In Tis Pity, the most effective use of language is through convincing an audience that Giovanni and Annabella have a natural, loving relationship. In Act One Scene Two, when Giovanni admits his love for Annabella and she responds evenly, he ends the scene with ‘After so many tears as we have wept, let’s learn to court in smiles , to kiss and sleep’. Finally Giovanni is no longer impassioned, ‘I have too long suppressed the hidden flames’, and is instead able to appreciate the natural rawness of their love. Not only that, but by referring to their ability to ‘weep, smile, kiss and sleep’, he is expressing emotions which audiences are able to relate to; proving that their relationship isn’t as unnatural as first assumed. During this particular moment, the audience become so engaged in the text that they forget about the theme of incest and instead support the  purity of their relationship. John Milton’s depiction of Satan creates a similar sense of curiosity into the ability to sympathise with him. This is highlighted when he observes Eve for the first time and becomes ‘of enmitie disarm’d/ of guile, of hate, of envie, of revenge’. The repetition of ‘guile, hate, envie, revenge’ proves how Satan is gradually striped of his emotions associated with evil, and is instead left vulnerable through his admiration. The power of Eve’s beauty forces him to become ‘abstracted’ from his own evil, thus demonstrating the ability to respond humanely. During this moment, Milton is allowing the audience the opportunity to make their own viewpoint of Satan; isolated from the conventional, one-dimensial presentation of him. The beauty of both texts is not caused by convincing the audience that sin is ‘attractive’, but instead pushing them into sympathising, admiring and simply enjoying pieces of literature beyond expectation.

Adlerian Psychology a Dolls House

Alfred Adler is a psychologist who developed a theory that can explain the characters’ actions in A Doll’s House. After many years of study, Adler realized the importance of motivation and how it affected people’s actions. This was later developed into a theory, known as the Adlerian Theory, which states that there must be a motivational force behind all behaviors (Fisher). Evidence of the Adlerian Theory is found in A Doll’s House by Henrik Ibsen through the actions of Krogstad, Torvald, and Nora. Family and friends are usually the most significant motivation to one’s actions because the concern for his or her family and friends will cause them to do whatever necessary to please them. The influence of family and friends may also affect one’s view of life and this would affect one to act differently in order to carry out his or her new attitude towards life (Boeree). An individual is part of a larger whole, the society, which means that one must to live up to society’s expectations to gain respect and acceptance (The Theory and Application of Adlerian Psychology). This demonstrates how a social setting can influence one’s behaviors. One’s primary goal in life is to gain acceptance and feel significant. The inferiority complex is when one feels a 2 lack of worth (Fisher). To overcome the inferiority complex, one must strive to reach a goal, known as the superiority complex (Fisher). In the process of the superiority complex, one will strive for perfection (Fisher). The determination to be a perfect individual forces one to act certain ways. Due to Krogstad’s desire to perfect his social status, he realizes the first step is to persuade Torvald into giving him his position back at the bank. In order to do so, he must blackmail Nora into convincing Torvald that he is more capable of the job than anyone else. Without a job, he is seen as lazy and worthless by his society, therefore, fighting for a position he believes he deserves would make others perceive him as someone who will fight for what he believes in. This delivers an image of a respectable man to society and this is what he wants. The feeling of worth and significance can cause confidence and security (The Theory and Application of Adlerian Psychology). Also, he wishes to grab every possible opportunity for his children, and without a job, the availability of these opportunities are limited. The pressure from Krogstad’s society to be respected and the love he has for his children caused him to do whatever he can to win back his job. Torvald however, is a very successful man when it comes to his job, but having his whole life revolve around it causes him to drift away from his family. He has become so attached to his new position at the bank and is so caught up with pleasing those around him that he reserves no time to spend 3 with his family. Torvald’s priority is to impress the society with his abilities and he puts his family second. Torvald’s motivation to keep him putting his everything in the bank is the respect he gets from the community. Even though the family is financially stable, he will not let Nora take money without his consent. Torvald treats Nora like a child and does not think of her as an equal to himself (Hardwick). He does this because he wants control over Nora and he craves the feeling of superiority. Because of the power and control Torvald wants over Nora, he refused Nora to borrow money when he was ill. However, Nora borrowed a large sum from Krogstad under her father’s name without Torvald’s knowledge. Nora did not consider the consequences when she forged her father’s signature because she was more concerned with Torvald’s health. Nora borrowed the money regardless of Torvald’s disapproval because she loved Torvald and could not risk him dying (Hardwick). Nora being treated the way she did by Torvald caused her to feel worthless. Torvald calls Nora by pet names which shows Torvald’s impression of her as a child. Nora and Torvald has never had an important conversation in all those years they have been married, meaning Torvald did not think Nora was intelligent or mature enough to understand important matters (Downs). This motivated her to leave Torvald and find her true self. Leaving Torvald was Nora’s way of overcoming the inferiority complex and the process of her finding herself is 4 her step into the superiority complex. In conclusion, one’s actions are caused by his or her societal surroundings or his or her personal desires. In A Doll’s House by Henrik Ibsen, Krogstad blackmailing Nora in order to get his position back in the bank is caused by his need to be accepted in society. Torvald’s control of all money coming in the household is caused by his desire to be superior to Nora. Nora’s decision to leave Torvald is caused by her need to find herself. The Adlerian Theory applies to these characters because they all have a motivational force behind their actions.

Financial Mangement Essay Example | Topics and Well Written Essays - 750 words

Financial Mangement - Essay Example electronic stock market. "With approximately 3,300 companies, the NASDAQ lists more companies and, on average, trades more shares per day than any other U.S. market" (NASDAQ, 2006, n/p). Therefore, the AMEX is a tangible physical entity, it occupies its own building and has physically designated space for trading - trading floor; has specifically designated members and an elected governing body. On the contrary, the NASDAQ, which means National Association of Securities Dealers Automated Quotation System, is a nebulous, intangible organization built up around the computerized system. The American Stock Exchange, according to its own definition, is "an auction market where prices for a diverse array of products - stocks, options, exchange traded funds (ETFs) and structured products - are determined by public bids to buy and offers to sell". The major characteristics of the trading process at the AMEX include: centralization of the order flow on the trading floor, priority given to the public orders, and execution of the orders by price and time sequence regardless of size or source. (AMEX, 2006, n/p). Like the AMEX, the NASDAQ operates as an auction market, but it has its own peculiarities: no physical trading floor is available and the orders flow goes solely through the automated quotation system. Additionally, unlike the AMEX specialists the NASDAQ dealers often maintain an inventory of the stocks that are traded less frequently. The AMEX system includes specialists, registered traders and floor dealers: "Trading in every Amex security is overseen by a specialist stationed on the trading floor . . . Specialists serve as facilitators, employing their extensive knowledge of the market in a security to bring together buyers and sellers, and helping them trade directly with each other. This skill is particularly important when large blocks of securities are brought to the floor" (AMEX, 2006, n/p). On the contrary, at the NASDAQ over-the-counter market trading in a particular security is not concentrated in the hands of the one particular specialist, and there is no monopoly, as the result. Any of the dealers interested in trading in this security can handle the orders on it. Trading at the AMEX can be performed in two ways: the orders can be processed either automatically, or manually. The automatic processing uses various systems as follows: "Member firms may route orders directly to the Exchange's trading floor through the Common Message Switch (CMS). After performing specific validation checks, CMS routes the orders to the Amex Order File (AOF), which retains order details and directs orders to the New Equity Trading System (NETS), Amex Options Display Book (AODB), Automatic Execution (Auto-Ex), or the firm's floor broker through the Booth Automated Routing System (BARS)" (AMEX, 2006, n/p). The orders may also be submitted manually by phone call to the broker or with help of a member firm's proprietary application: "In both cases, immediately upon receipt, the floor broker will "systematize" the order by entering it into the Amex Order File using the order entry feature of the Booth Automated Routing System (BARS) terminal. Once "systematized" these orders may be printed and

Assess the difficulties confronting Americas response to the attacks Essay

Assess the difficulties confronting Americas response to the attacks of 11th September 2001 - Essay Example To safeguard people’s interests, new strategies and plans were required to be developed and enforced. Laws needed to be framed to make Americans feel safe emotionally, physically and politically. Therefore, the US Patriotic Act was amended and renamed ‘USA Patriot and Terrorism Prevention Reauthorization Act’. It was made more stringent and extra statutes included with wide ranging terrorists relating offences like deliberate and destructive activity against the state or its people resulting in loss of life or property, money laundering, surveillance and detention of people under suspect of terrorist activities etc. with capital punishment introduced. While such stringent measures are incorporated in the constitution, implementation is increasingly becoming tougher because of the multicultural fabric of the society in America. It is very important to understand the motivations behind the terrorism when engaged in counterterrorism efforts, mainly because today the terrorism has become high tech and spread globally, infiltrating the society to the extent that if not handled with cautious and premeditated techniques and strategies, involving the in-depth analysis of the socio-psychological background of the terrorist, it would be extremely difficult to take effective steps to countermand their intended actions, targeting the innocents and holding them to ransom. The general motives of the terrorists in this country and abroad involve coercive tactics and unlawful intimidation of the government bodies to force the government to accede to their vested interest regarding political, ideological or religious demands. Terrorists are people or individuals who commit intended violence against the innocents with the sole intention of harming the public and destroying the property in order to make them meet their vested political goals and religious fanatics’ demands. â€Å"For our terrorist enemies,

Disaster Management System Essay Example | Topics and Well Written Essays - 1000 words

Disaster Management System - Essay Example More often, the damage is so sudden that all precautionary and preventive measures fail. For example, the hurricane that caused the devastation of Smallville, Florida led to a complete revision of the city's disaster management system. Hence, we define our problem, "there is a need to establish emergency management systems where they are not aligned and strengthen such systems where already applied". After defining the problem we can establish the objective of this essay as "design, develop and ensure successful implementation of a disaster management system which minimizes the probability of destruction caused by a disaster, whether natural or man-made." It is evident that survival chances after a disaster are widely improved if people, governments, organizations and emergency services have sufficient preparation of essentially required plans and equipments. Such measures are highly dependent on the location and can vary with the kind of disasters that may occur in the area. This give rise to the concept of disaster management which is basically a process of continous planning aimed at prevention.. Disaster management therefore refers to programs and measures designed to prevent, mitigate, prepare for, respond to and recover from the aftereffects of disasters. Activities that are designed to reduce the risks of damage caused to public through disasters come under mitigation. It involves continous efforts to educate governments, organizations and general public on measures they can take to diminsh loss and injury. Thus, mitigations attempt to prevent the disaster from occurring, or reduce its effects. For example, projects like raising the level of a city and efficient drainage system can prevent floods to cause massive damages. Preparedness Preparedness sets out a series of measures to prepare the masses to tackle with natural or man-made disasters. Usually a policy is directed by the government to prepare for nonmilitary civil emergencies before they happen. Many cities also offer training for community emergency response team. Training is provided to teams of amateur emergency workers in every neighborhood. These are truly useful because in an emergency, emergency service providers are instantly overloaded. The trained amateurs can handle emergency rescues instantly and assist professional emergency services. Response The degree of responsiveness of emergency management services is cruical in minimizing the effects of disaster. A very common problem however is the lack of trained respondents in case of mass emergencies. There are always fewer people handling the situation and larger people suffering from it. Recovery Rebuilding damaged infrastructure and restoring people to their normal course of life is covered under the recovery phase. The essential recovery is to repair bridges and roads so as to give access to rescue teams to the affected areas as well as provide exit routes for the people affected by the disaster. Roads also provide a way to delivering essential supplies like food and water. It is important to understand that all four phases work together. For instance, if the mitigation phase is flawed, the recovery phase even if strong is going to suffer. Human behavior in a Moment of Crises Panic is the right word to define the immediate response of people.

Economic read an article Essay Example | Topics and Well Written Essays - 1250 words

Economic read an article - Essay Example In as much as many governments are institutions set on social contracts, there is a serious failure in the effectiveness to deliver according to set standards granted by the provisions of the social contracts. According to Leeson, a legitimate social contract should attest to three chief concerns. First, the contact must serve the purpose of granting political power. I should be in accordance with the joint consent of all subjects or stakeholders whose interest are represented in the contract. The main intent of the contract should be to facilitate social collaboration. The key consideration in the formation of a social contract is its aim of creating a government (Leeson 444). Leeson identifies the second most important feature of a social contract while referring to the original state before the formulation of the social contract. A social contract should serve the purpose of bringing the various stakeholders in the contract from a situation of no prior contract. The people whose i nterests are expressed in the contract should be in need a forum that can attend to their claims including their appeals. This, according to Leeson, is fundamental since it eliminates the possibility of conflicts and enhances sovereignty. If there is an existing sovereign body and an agreement is drafted which is legitimate, it does not qualify as a social contract. Instead, it is a contract. It does not replace the social contract that existed prior to its formation and, therefore, only remains as a contract. The third characteristic of social contracts identified by Leeson is the recognition that the agreement resulted from voluntary acceptance and approval by all parties subject to its provisions. Should any member of the society expresses disapproval of the social contract, then it no longer becomes a social contract. Every member whose welfare and other aspects of life are subject to the provisions of the social contacts should consent to it (Leeson 445). Disapproval by even on e member of the society renders it unbinding to the entire population affected by it. Should there be part of the population that is in disagreement, at the time of signing, then it should constitute part of the population not bound by the provisions of the contract. Following the absence of the three prerequisites that make up a social contract in most governments, Leeson argues that not all social contracts are genuine. In Leeson’s account, early social contracts that formulated most present day governments did not meet the three requirements that should be the threshold of a legitimate social contract. Following the argument that social contracts should bear the main objectives of forming a government, Leeson renders these early contracts as out of the desired intention. Their formation was legitimately promoted by the desire to gain political rule over the people. Further concerns emanate from the approval of conceptual unanimity that never follows its provisions, as well . The emergence of pirate societies, as outlined by Leeson, did restore the legitimacy of the social contract concept. This was a possibility given the fulfillment of actual unanimity that is vital in meeting the threshold of a social contract based on the three pillars of its formation. As Leeson states, the system of constitutional democracy embraced among the

Mans dark past Essay Example | Topics and Well Written Essays - 1000 words

Mans dark past - Essay Example This paper explores this literature by focusing on three short stories to determine the significance of literature in illuminating on the shadowy plane of humanity. Good Men Are Hard To Find In â€Å"Good men are hard to find† the author initially portrays a horror story, but in the end it becomes a religious tale in which there is a determination of how good and evil are distinguished. The story is seen through a grandmothers’ point of view, the lead character in the story. She represents the old generation who are religious, and is tormented by the modern world, and thus, hard to please in any way. Every person around her appears to be flawed as she says that they lack respect or just because they are tired of dealing with her high expectations. However, what the grandmother does not realize is that her old judging ways were also flawed, for if she stopped dwelling in the past and opened her eyes to life realities she could have saved the whole family from the misfit. Therefore, the title of the story is the representative of the grandmother’s assertion of then changed society, and this is evident when Red Sam’s wife states; â€Å"It isn’t a soul in this green world of God’s that you can trust†¦ And I don’t count nobody out of that, not anybody, as she is looking at her husband† (O’Connor 370). Therefore, the story has more to just a family going for a vacation away from home, for it contains prefigures that allude to the conclusion of the story. This is depicted in the conversations of characters, especially the grandmother and children’s mother whom have been used as symbols of the old and the new to bring out lessons to the human kind (DiYanni, 322). This show how good and evil has continued to have a never ending battle through the eyes of O’Connor. Greasy lake The second short story â€Å"Greasy Lake† is characterized by rape, death, alcohol and drugs all of which ar e attributes held by the bad boys in the story (Walker, 257). The main character who is the author begins the story by the description and that of his friends as a bad character. This is depicted in the way they dress: â€Å"we wore torn-up leather jackets, slouched around with toothpicks in our mouth, sniffed glue and ether and what somebody claimed was cocaine† (Walker, 250). Therefore, in as much as the narrator has described the greasy lake to be a dangerous place, it is where they chose to spend their days and late nights just to be termed as bad boys (Boyle, 130). However, as it turns out, this lake seems to be a symbol that is used to convey the deterioration of morals in the society. This is because as the narrator says, the current waters of the lake were not the same as in the past, which made the Indians who were the original inhabitants of the place name it Wakan in reference to the clarity of its waters. Therefore, this change of waters from the time of Indians a s clear to murky is a sure enough example to communicate the corruption of the current morals of the societal context. The lake symbolizes the decadence in morals, especially the youth culture. This is a depiction of how man can only look back into his history to derive lessons. This is so because during the time the Native Americans lived there, they took care of the

Flight Ready Dashboard Research Paper Example | Topics and Well Written Essays - 3500 words

Flight Ready Dashboard - Research Paper Example This is to say and mention that the general equipment and technical awareness or strength of the aircraft has also been improved and bettered. In history, the dashboards have been changed and modified since the period of the 1970s. At first, the aircraft dashboard has changed and grown from analogue to digital formats. The irreducible minimum in this line of thought is that the dashboards have been used to form decision support systems. In principle, in the period of 1990s, saw the dashboard industry undergo a tremendous impact and change in the technological improvements (Boman, 1995). This was particularly, the period where the web and the internet gained prominence in the world as a means and avenue of communication and conduit to information. Thus, the manufacturers of the dashboards had to conform to the changes and improvements which were happening on the internet and the webs. The basic irreducible principle and format in the dashboard was developed to gather and collect information from all the other parts of the airplane. At first, the initial making of the dashboards was that they were fixed and built in the cockpit. However, as the times progressed, the developers and the manufacturers of the dashboards have developed dashboards which are fixed outside the box. This paper will thus examine in details, the growth and the advancement of the flight ready dashboard over the years. In principle, the developers of the dashboards have also ensured that the evolved dashboards have ensured that the benefits of the digital dashboards have cutting edge benefits. In prospect, the flight ready dashboards have been modified into executive and top of the art systems. Subsequently, the flight ready benefits have some advantages and benefits over the initial dashboards which were developed. They include visual presentation of the data and trace the performance of